Quinine And Blood Pressure Medication

Uses
- What Is Quinine and How Does It Work?
Dosage
- What Are Dosage of Quinine?
Side Effects
- What Are Side Effects Associated with Using Quinine?
Drug Interactions
- What Other Drugs Interact with Quinine?
Warnings and Precautions
- What Are Warnings and Precautions for Quinine?

Brand Name: Qualaquin

Generic Name: Quinine

Drug Class: Antimalarials

What Is Quinine and How Does It Work?

Quinine is a prescription drug used as an antimalarial drug indicated only for the treatment of uncomplicated Plasmodium falciparum malaria. Quinine sulfate has been shown to be effective in geographical regions where resistance to chloroquine has been documented.

Quinine is available under the following different brand names: Qualaquin.

What Are Dosage of Quinine?

Dosage of Quinine:

Adult and Pediatric Dosages

Capsule

324 mg

Dosage Considerations – Should be Given as Follows:

Malaria

Adults

Uncomplicated (P. falciparum)

648 mg orally every 8 hours for 7 days

Chloroquine-Resistant (P. falciparum)

648 mg orally every 8 hours for 3-7 days concomitant tetracycline, doxycycline, or clindamycin

Chloroquine-Resistant (P. vivax)

648 mg orally every 8 hours for 3-7 days concomitant doxycycline (or tetracycline) and oral primaquine

Pediatric Dosages

Uncomplicated (P. falciparum)

30 mg/kg/day orally divided three times daily for 3-7 days
Should not exceed the usual adult oral dosage

Chloroquine-Resistant (P. falciparum)

30 mg/kg/day orally divided three times daily for 3-7 days, with concomitant doxycycline, tetracycline, or clindamycin
Should not exceed the usual adult oral dosage

Chloroquine-Resistant (P. vivax)

30 mg/kg/day orally three times daily for 3-7 days, with concomitant doxycycline and oral primaquine
Should not exceed the usual adult oral dosage

Babesiosis

Adult Dosage:

648 mg orally every 8 hours, with concomitant orally or intravenously clindamycin

Pediatric Dosage:

25 mg/kg/day orally divided three times daily for 7 days, with concomitant oral clindamycin

Dosage Modifications

Severe, chronic renal impairment: 648 mg orally once, then 324 mg orally every 12 hours

Hepatic impairment

Mild or moderate (Child-Pugh A or B): No dosage adjustment required; monitor closely
Severe (Child-Pugh C): Do not administer

SLIDESHOW

Fungal Skin Infections: Types, Symptoms, and Treatments See Slideshow

What Other Drugs Interact with Quinine?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

Quinine has no known severe interactions with other drugs.
- Serious interactions of quinine include:
- cisapride
- dronedarone
- eliglustat
- pimozide
- thioridazine
Quinine has serious interactions with at least 48 different drugs.
Quinine has moderate interactions with at least 138 different drugs.
Quinine has minor interactions with at least 82 different drugs.

This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns, or for more information about this medicine.

What Are Warnings and Precautions for Quinine?

Warnings

Limited or no benefit for treatment/prevention of nocturnal leg cramps
May cause serious and life-threatening hematologic reactions, including thrombocytopenia and hemolytic uremic syndrome/thrombotic thrombocytopenic purpura (HUS/TTP)
Chronic renal impairment associated with the development of TTP has been reported
This medication contains quinine. Do not take Qualaquin if you are allergic to quinine or any ingredients contained in this drug
Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately

Contraindications

Hypersensitivity
G6PD deficiency
Optic neuritis, tinnitus, history of quinine-associated blackwater fever, and thrombocytopenic purpura
Pregnancy

Effects of Drug Abuse

No information available

Short-Term Effects

See "What Are Side Effects Associated with Using Quinine?"

Long-Term Effects

See "What Are Side Effects Associated with Using Quinine?"

Cautions

Reduce parenteral dose by half if over 48-hour parenteral treatment required; monitor EKG, blood pressure, and glucose with parenteral treatment
FDA warns against unapproved use for leg cramps because of unpredictable serious and life-threatening hematologic reactions including thrombocytopenia and hemolytic-uremic syndrome/thrombotic thrombocytopenic purpura (HUS/TTP)
QT prolongation
Concentration-dependent prolongation of the PR and QRS interval observed
At particular risk are patients with underlying structural heart disease and preexisting conduction system abnormalities, elderly patients with sick sinus syndrome, patients with atrial fibrillation with the slow ventricular response, patients with myocardial ischemia, or patients receiving drugs known to prolong the PR interval (verapamil) or QRS interval (flecainide or quinidine)

Pregnancy and Lactation

Do not use quinine during the first trimester of pregnancy
The risks involved outweigh potential benefits
Safer alternatives exist
Quinine enters breast milk. Consult your physician if breastfeeding

QUESTION

Bowel regularity means a bowel movement every day. See Answer

From

References

Medscape. Quinine.
https://reference.medscape.com/drug/qualaquin-quinine-342696#0
RxList. Qualaquin Monograph.
https://www.rxlist.com/qualaquin-drug.htm

Source: https://www.rxlist.com/consumer_quinine_qualaquin/drugs-condition.htm

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Reginald Teicher